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The Role of the Glymphatic System in Neurodegeneration
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The “Centro Dino Ferrari” has launched a research project aimed at studying the role of the glymphatic system in the progression of neurodegenerative dementias. The project seeks to identify reliable and non-invasive biomarkers to assess glymphatic system activity, as well as to uncover biological mechanisms that can be modulated through pharmacological interventions or non-invasive techniques.
This study is particularly relevant because glymphatic system dysfunction may contribute to the accumulation of toxic proteins, thereby promoting the development of dementias such as Alzheimer’s disease. The initiative is part of a broader multidisciplinary research network, involving experts in neurology, brain imaging, and molecular biology.
Methods and Technologies
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Advanced neuroimaging: Use of Magnetic Resonance Imaging (MRI) to analyze cerebrospinal fluid flow and monitor glymphatic system activity.
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Biological fluid analyses: Assessment of biomarkers in cerebrospinal fluid to detect alterations associated with dementia progression.
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Experimental models: Studies in animal and cellular models to understand the mechanisms underlying glymphatic dysfunction.
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Innovative monitoring technologies: Development of tools for the indirect measurement of glymphatic system efficiency in patients.
Expected Impact
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Identification of early biomarkers to detect disease before the onset of clinical symptoms.
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Development of targeted therapeutic strategies to improve glymphatic system efficiency and reduce the risk of neurotoxic protein accumulation.
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Improvement of patients’ quality of life by slowing disease progression through personalized interventions.
Budget: €105,000
Contatti e approfondimenti
Contact: Dott. Andrea Arighi
mail: andrea.arighi@policlinico.mi.it
Questo progetto è supportato da
“Supports the project with a donation of €105,000, distributed over three years.”