Preventing Parkinson’s Disease: Between Cellular Stress and Genetics

Parkinson’s disease is one of the most common neurodegenerative disorders and is characterized by the gradual loss of dopaminergic neurons, which are essential for movement control. To date, there is no definitive cure, and the causes underlying disease development remain largely unknown. However, it is believed that a complex interplay between genetic and environmental factors contributes to its onset. In genetically predisposed individuals, external events such as infections, physical trauma, or severe emotional stress may trigger cellular mechanisms that initiate neurodegeneration.

In this project, researchers at the “Centro Dino Ferrari” aim to investigate the role of cellular stress response as a potential trigger in vulnerable individuals, with the goal of identifying new therapeutic targets and developing strategies for prevention or early intervention.