Services and laboratories » Unità Operativa Semplice – (U.O.S.) Diagnostica delle Malattie Neuromuscolari » Tissue Bank



Bank of Dna cell line and nerve-muscle-cardiac tissues

Curator: Prof. M. Moggio
Co-responsible: Dr M. Sciacco

The Bank has been partially funded by Telethon foundation since 1999 (present project GTF 02008, 3 year duration).Since January 2002 the Bank has become one of the partners of the Eurobiobank Network, sponsored by the European Community, under the Coordination of Eurordis (European Organization for Rare Disorders).The Bank is held in collaboration with Prof. N. Bresolin and Dr. G.P. Comi of the Laboratory of Biochemistry and Molecular Genetics of Dipartimento di Scienze Neurologiche, University of Milan, Ospedale Maggiore di Milano. (Director Prof. N.Bresolin).

Tel.: 0039-02-55033966
Fax: 0039-02-55033827
E-mail: maurizio.moggio@unimi.it

The Bank is updated December 2009
The existence of selected banks for neuromuscular samples allows the collection of a consistent number of specimens per single disease and therefore examination of the same by experienced people for both research and diagnostic purposes. The Bank presently stocks slides of histology, histochemestry and immunohistochemistry from 9102 bioptic specimens, 5218 skeletal muscle samples, 15 cardiac muscles, over 2620 embedded samples for ultrastructural studies, 461 peripheral nerve specimens for morphological studies. Besides, 4322 muscle specimens for biochemical studies, 3304 DNA samples and 1139 muscle cell cultures are also available (see below). All specimens were obtained after informed consent from patients affected with different neuromuscular disorders.-The existence of selected banks for neuromuscular samples allows the collection of a consistent number of specimens per single disease and therefore examination of the same by experienced people for both research and diagnostic purposes.-The Bank routinely accepts biological material from other hospitals or laboratories for genetic, morphological and biochemical analyses.
» For information see "in samples”.

The described procedures are expensive and time-consuming and the amount of sample available is limited. For this reason, the curator of the Bank needs an appropriate documentation about both diagnostic and research projects for any sample requested. Also, once the research work is completed and published, each investigator is requested to quote the Bank as the source of the samples studied.
» For information see "out samples”.

Biological Samples

Biological samples are presently classified as follows:

TISSUE SAMPLES, DNA AND CELLS STORED

Muscle = 5218 ; Nerve= 461 DNA= 3304 ; fibrogenic cell line =605 ;
muscle cell line=646; Muscle for biochemical studies=4322

Until 31st December 2009